This project focuses on the modeling of anti-solvent crystallization for pharmaceutical systems. Anti-solvent crystallization has many advantages over the widely used evaporative method for two key reasons. The first is that it doesn't require energy to boil the solvent away. This will lower the operating costs of the process. The second is that the solute may have a low temperature dependent solubility in its solvent. This would make it difficult to crystallize the product via evaporative crystallization.

The first aim of the project is to create a generic model for crystallization in gPROMS. This will ensure rapid simulations to be done for any given solute and solvent system. It will also help find which anti-solvent gives the desired crystal distribution for a given system. Optimization of this model will then be carried out, in order to generate the desired crystal distribution.

The optimized model will be verified against laboratory data. Once the model has been verified, the model will be inserted into a real time process pilot plant. In the pilot plant, model-based control will be implemented to control the crystal size distribution online.